ARTYKUŁ

Abayomi T. Ogunjimi, Gbenga Alebiowu

Material and tableting properties of Azadirachta indica gum with reference to official acacia gum
2014-02-17

Abstract: This study determined the material and tableting properties of Azadirachta indica gum (NMG) relative to acacia gum (ACA). The morphological properties were assessed with size and shape factors of aspect ratio, roundness, irregularity and equivalent-circle-diameter. The tableting properties of the gums were determined using compressional characteristics, tensile strength (TS), brittle fracture index (BFI) and crushingstrength-friability/disintegration-time ratio (CSFR/DT). The results suggest that NMG possesses larger, irregular and more elongated particles than ACA. The onset and amount of plastic deformation occurring in NMG was faster and higher, respectively, than in ACA. The result shows that, although ACA tablets were stronger, their tendency to cap/laminate was higher than in NMG tablets. The NMG tablets possess lower DT than those of ACA, while the CSFR/DT result suggests that a better balance exists between the strength and weakness of NMG tablets. The study concluded that NMG can be a useful excipient in tablet formulation.


Keywords: neem gum, acacia gum, tensile strength, brittle fracture index, disintegration, crushing strength-friability/ disintegration-time ratio

Material and tableting properties of Azadirachta indica gum with reference to official acacia gum

904.96 kB | 21 grudnia 2017