ARTYKUŁ

Andrzej Stańczak

Leki przeciwnowotworowe. Interkalatory
2006-02-16

Anticancer drugs. Intercalators. The discovery of new compounds with antitumoral activity has become one of the most important goals in medicinal chemistry. One interesting group of chemotherapeutic agents used in cancer therapy comprises molecules that interact with DNA. Intercalators are the most important group of compounds that react reversibly with the DNA double helix. Some of them are valuable drugs currently used for the treatment of ovarian and breast cancers and acute leukemias, while many others are in different phases of clinical trials. In this work we will focus on compounds that act as classical intercalators or bisintercalators and have displayed an interesting antitumor activity based on inhibition topoisomerase II. They have been classified according to the structure of the chromophore. This review have described of some intercalators that will be classified as nonclassical intercalators.