Wojciech Andrzej Linka

Solubilizacja niesteroidowych leków przeciwzapalnych biogennymi aminokwasami w stałych doustnych postaciach leku

Solubilization of non-steroid anti-inflammatory drugs by biogenic amino-acids in solid oral drug forms. The possibility of aspartic acid, glycine and L-asparagine application as solubilizers of non-steroid anti-inflammatory drugs: acetylsalicylic acid (ASA) has been assessed. Oral solid forms of drugs (uncoated tablets) were produced, containing ASA together with solubility mediators (aspartic acid, glycine and L-asparagine) and pharmaceutic availability of the obtained adducts was determined.