Katarzyna Sosnowska, Katarzyna Winnicka

Ocena Veegum- (krzemianu magnezowo-glinowego) jako substancji pomocniczej w zawiesinach z paracetamolem lub siarką

Veegum?(magnesium-aluminium silicate) as stabilizer in paracetamolum or sulphur suspension. Since most of the pharmaceutical suspensions are aqueous, a viscosity-increasing agents have to be used. Suspending agents can be divided into two main categories: organic polymers (e.g. tragacanth, xanthan gum, methylcellulose, hydroxyethylcellulose, carbomer, polyvinyl alcohol) and inorganic agents (e.g. colloidal silicon dioxide - Aerosil, bentonite and special purified natural smectite clay - Veegum?). Veegum?is valued for its ability to swell in water and for its useful rheological properties in aqueous compositions. The aim of this study was to evaluate the influence of Veegum?on the stability of paracetamolum and sulphur suspension. The results revealed that 2.5% Veegum?gave the best formulated suspension for paracetamolum, as compared to 2% hydroxyethylcellulose and 0.25% xanthan gum. On the other hand, Veegum? can not be used as stabilizer in sulphur suspension, because sulphur destabilizes smectiteęs colloidal structure.