Adrian Doroszko, Andrzej Szuba

Aktualne spojrzenie na etiopatogenezę i terapię nadciśnienia tętniczego

Actual view on etiopathogenesis and therapy of hypertension. In 2000, 26% of the adult population worldwide had hypertension and the prevalence is estimated to rise by 2025 up to 40%. Hypertension is related with an increased risk of stroke and another cardiovascular disorders, however the pathogenesis of hypertension is still investigated and remains not fully explained. In 2007, the European Society of Hypertension (ESH) and European Society of Cardiology (ESC) have revised their previous recommendations because of advances in diagnosis and treatment. The update is based on a critical review of data from randomized clinical trials and from observational studies. The main goal of treatment of hypertension is to achieve the maximal reduction in the total risk of cardiomorbidity and mortality but also improvement of the quality of life. This article presents current opinions on pathogenesis of hypertension, especially in aspects of disfunction of endothelium, which plays a crucial role in the maintenance of vascular tone and structure. Actual strategies of treatment and conceptions on new antihypertensive drugs are also presented.