ARTYKUŁ

Alicja Bieńkowska, Żaneta Słyk, Edyta Banaczkowska-Duda, Maciej Małecki

Formulacje leków genowych, recepty genowe
2018-10-25

Gene formulations, gene prescriptions

Gene therapy as a modern method of the treatment for diseases, that were considered incurable until recently, sets new directions for the development of present medicine. Despite the increasing number of experimental trials, the challenge for gene therapy is to define genes with therapeutic potential and search for effective carriers, pharmaceutical forms for gene preparations. Currently, the most commonly used vectors are constructs based on viral genomes: adenovirus, retrovirus, AAV – adeno-associated virus. The gene preparations are administered as injections, however in vitro and in vivo studies indicate the therapeutic efficacy of other formulations: solid and semi-solid forms, moreover, “gene prescriptions” are designed. European Pharmacopoeia 6 (Polish Pharmacopoeia VIII) was the document that established the position of gene products in pharmacy and medicine. The appearance of new gene drugs (Glybera, Strimvelis) indicates the development of gene therapy and the classical pharmacy recipe.

Keywords: gene therapy, gene formulations, gene prescriptions, pharmacopeia.

© Farm Pol, 2018, 74(10): 611-615

Formulacje leków genowych, recepty genowe

283.69 kB | 29 kwietnia 2019